PROSPECT II: protein structure prediction program for genome-scale applications
نویسندگان
چکیده
منابع مشابه
PROSPECT-PSPP: an automatic computational pipeline for protein structure prediction
Knowledge of the detailed structure of a protein is crucial to our understanding of the biological functions of that protein. The gap between the number of solved protein structures and the number of protein sequences continues to widen rapidly in the post-genomics era due to long and expensive processes for solving structures experimentally. Computational prediction of structures from amino ac...
متن کاملProtein Structure Prediction Ii
Jeffrey Skolnick ,2 Yang Zhang Because the molecular function of a protein depends on its three dimensional structure, which is often unknown, protein structure prediction is an essential tool in proteomics. The state of the art of protein structure prediction is reviewed with emphasis on knowledge-based comparative modeling/threading approaches that exploit the observation that the protein dat...
متن کاملTowards genome-scale structure prediction for transmembrane proteins.
In this paper we briefly review some of the recent progress made by ourselves and others in developing methods for predicting the structures of transmembrane proteins from amino acid sequence. Transmembrane proteins are an important class of proteins involved in many diverse biological functions, many of which have great impact in terms of disease mechanism and drug discovery. Despite their bio...
متن کاملChapter 11: Genome-wide protein structure prediction
The post-genomic era has witnessed an explosion of protein sequences in the public databases; but this has not been complemented by the availability of genome-wide structure and function information, due to the technical difficulties and labor expenses incurred by existing experimental techniques. The rapid advancements in computer-based protein structure prediction methods have enabled automat...
متن کاملGenome-wide Membrane Protein Structure Prediction
Transmembrane proteins allow cells to extensively communicate with the external world in a very accurate and specific way. They form principal nodes in several signaling pathways and attract large interest in therapeutic intervention, as the majority pharmaceutical compounds target membrane proteins. Thus, according to the current genome annotation methods, a detailed structural/functional char...
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ژورنال
عنوان ژورنال: Protein Engineering Design and Selection
سال: 2003
ISSN: 1741-0126,1741-0134
DOI: 10.1093/protein/gzg081